Enteric neural stem cell therapies for enteric neuropathies
نویسندگان
چکیده
منابع مشابه
White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.
Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and gl...
متن کاملEnteric Neurospheres Are Not Specific to Neural Crest Cultures: Implications for Neural Stem Cell Therapies
OBJECTIVES Enteric neural stem cells provide hope of curative treatment for enteric neuropathies. Current protocols for their harvesting from humans focus on the generation of 'neurospheres' from cultures of dissociated gut tissue. The study aims to better understand the derivation, generation and composition of enteric neurospheres. DESIGN Gut tissue was obtained from Wnt1-Cre;Rosa26Yfp/Yfp ...
متن کاملPediatric enteric neuropathies: diagnosis and current management.
PURPOSE OF REVIEW Neurointestinal diseases are increasingly recognized as causes of significant gastrointestinal morbidity in children. This review highlights the most common pediatric enteric neuropathies and their diagnosis and management, emphasizing insights and discoveries from the most recent literature available. RECENT FINDINGS The embryologic and histopathologic causes of enteric neu...
متن کاملNeural crest regionalisation for enteric nervous system formation: implications for Hirschsprung's disease and stem cell therapy.
Midbrain, hindbrain and vagal neural crest (NC) produced abundant enteric nervous system (ENS) in co-grafted aneural hindgut and midgut, using chick-quail chorio-allantoic membrane grafts, forming complete myenteric and submucosal plexuses. This ability dropped suddenly in cervical and thoracic NC levels, furnishing an incomplete ENS in one or both plexuses. Typically, one plexus was favoured o...
متن کاملA quantitative cell migration assay for murine enteric neural progenitors.
Neural crest cells (NCC) are a transient and multipotent cell population that originates from the dorsal neural tube and migrates extensively throughout the developing vertebrate embryo. In addition to providing peripheral glia and neurons, NCC generate melanocytes as well as most of the cranio-facial skeleton. NCC migration and differentiation is controlled by a combination of their axial orig...
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ژورنال
عنوان ژورنال: Neurogastroenterology & Motility
سال: 2018
ISSN: 1350-1925,1365-2982
DOI: 10.1111/nmo.13369